تاثیر قارچ Cordyceps militaris روی تیپ دو دیابت در موش
Abstract
Controlling hyperglycemia and dyslipidemia is associated with reduced risks for diabetic complications. The present study examined the effect of dongchunghacho (Cordyceps militaris; CM) on hyperglycemia and dyslipidemia in an animal model of type 2 diabetes. Fiveweek-old db/db mice were fed an AIN-93G diet or a diet containing 1% CM water extract, whereas db/+ mice were offered the AIN-93G diet for 6 weeks. Consumption of CM significantly decreased blood glycated hemoglobin and serum glucose levels, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in db/db mice. CM significantly lowered serum triglyceride and total cholesterol levels, and increased HDL-cholesterol level. CM water extract inhibited rat intestinal α-glucosidase, with an IC50 of 182 μg/mL in vitro. These results indicate that CM exerted hypoglycemic and hypolipidemic effects in db/db mice.
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مقاله 2012,
تاثیر قارچ Cordyceps militaris روی تیپ دو دیابت د
